Patient care innovations

Scientific advances to the benefit of patients

Some doctors at the origin of Liryc project have contributed to three key discoveries in the field of cardiac electrophysiology. To cure arrhythmias and improve heart failure, patients now benefit from ablation and resynchronization therapies. 

 

Liryc leads many projects to enhance and continually optimize these therapies for the benefit of patients.

 

The Bordeaux University Hospital’s Cardiac cardiac eElectrophysiology service has the highest activity rate in France for  cardiacfor cardiac electrical tissue interventions (approximately 1000) and pacemaker and defibrillator implantations (approximately 800). The Cardiac Electrophysiology-Cardiology service of the University Hospital of Bordeaux has the highest activity in France with approximately 1000 interventions on cardiac electrical tissues and 800 implantations of pacemakers and defibrillators. Patients from all over France, Europe and worldwide are treated here.  

Thermoablation of atrial fibrillation

In the 90s, Liryc doctors identified the triggers of atrial fibrillation ("sparks") in the pulmonary veins. This landmark discovery led to the development of a curative treatment of this disease. It consists of cauterizing the pulmonary veins by a radiofrequency catheter so as to exclude these arrhythmia triggers. This approach has become the treatment of reference: to date, over 300,000 patients are treated annually worldwide.

Thermoablation of ventricular fibrillation

Applying the same approach for ventricular fibrillation, these doctors have identified the triggers of sudden death as due to ventricular fibrillation.These triggers are located in the electrical system of the heart, called the Purkinje network. This electrical network is essential for heart contraction and represents only 2% of the ventricular mass! The localized destruction of these arrhythmogenic sources by thermoablation represents an innovative and curative approach to ventricular fibrillation in order to prevent sudden death.

Cardiac resynchronization in heart failure

Some Liryc doctors participated in the development of cardiac resynchronization in heart failure.This electrical therapy consists of implanting pacing leads in the ventricular chambers. It aims to specifically correct the electrical dysfunctions in order to harmonize the contraction of the ventricles and provide better cardiac output.

Major challenges

Currently, the major challenges of Liryc are :

  • for atrial fibrillation :
    • to develop better ablation tools for safer, faster and easier procedures, with shorter length of hospitalization
    • to develop drug therapy targeting venous cells
    • to develop biomarkers to allow an identification at an early stage of the disease, as well as new therapeutic strategies.
  •  for ventricular fibrillation :
    • to identify populations at risk of sudden death from ventricular fibrillation
    • to develop biomarkers
    • to develop drug targets on Purkinje network.
  • for heart failure :
    • to understand its electrical dysfunctions
    • to understand how cardiac resynchronization improves myocardial function and prognosis
    • to enable more patients to benefit from cardiac resynchronization therapy

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