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International projects

ECSTATIC

Electrostructural Tomography – Towards Multiparametric Imaging of Cardiac Electrical Disorders 

 

The aim of the ERC project is to advance knowledge about the characterisation of cardiac electrical disorders and so create new tools for diagnosis and treatment by developing a new non-invasive method (electrostructural tomography), combining magnetic resonance and non-invasive cardiac mapping.

 

The project received funding from the “European Research Council” as part of the ‘Horizon 2020’ programme: EU research and innovation programme from 2014 to 2020:  ERC-2016-STG, (Research Agreement No. 715093).

To know more ECSTATIC

RECH - Microcard

   MICROCARD - Numerical modeling of cardiac electrophysiology at the cellular scale

 

Cardiovascular diseases are the most frequent cause of death worldwide and half of these deaths are due to cardiac arrhythmia, a disorder of the heart's electrical synchronization system. Numerical models of this complex system are highly sophisticated and widely used, but to match observations in aging and diseased hearts they need to move from a continuum approach to a representation of individual cells and their interconnections. This implies a different, harder numerical problem and a 10,000-fold increase in problem size. Exascale computers will be needed to run such models.

We propose to develop an exascale application platform for cardiac electrophysiology simulations that is usable for cell-by-cell simulations. The platform will be co-designed by HPC experts, numerical scientists, biomedical engineers, and biomedical scientists, from academia and industry.

This project has been selected for funding under the European Horizon 2020 program.

PUSHCART

Personalized MultiSystems simulations for Honing Cardiac Resynchronization Therapy

 

This project will combine the electrical, mechanical and haemodynamic function in the most detailed, multiphysics and multiscale representation of the heart to date.

Validation of experimental, retrospective and prospective studies will help us to develop a predictive tool to determine optimal CRT lead placement in cardiac resynchronization therapy.

 

This project received funding from ERA-Net ERACoSysMed, “collaboration on systems medicine funding to promote the implementation of systems biology approaches in clinical research and medical practice" (Agreement No. ANR-15-CMED-0003-01)

 
PIC (MSCA ITN)

  Personalised in silico cardiology

 

Advances in computer and simulation technology nowadays allow us to analyse unpublished clinical data in silico (via computer models), to visualise the early detection of conditions using model-based diagnostic biomarkers and to design personalised therapies using predictive models. The in-silico tools also reduce the use of animals in developing new cardiac therapies and medication.

PIC is a European, MSCA-ITN type project, which will train the cohort of 15 future leaders of innovation, capable of formulating and achieving the vision of Personalised In-silico Cardiology (PIC).

IHU Liryc is a partner in this European project co-ordinated by King's College London

MULTIFIB

ERA-CVD Joint Transnational Call 2018 “Transnational Cardiovascular Research Projects driven by Early Career Scientists”

Multimodal fibre optic probe for highly resolved in vivo localization of cardiac fibrosis

 

People with structural heart disease are often only diagnosed during an episode of sudden cardiac death, particularly women. Therefore, only a minority of patients is eligible for targeted treatment, such as catheter ablation therapy. There is a gender imbalance and difficulty in identifying and locating the combined electrical, structural or biochemical substrates which predispose individuals to ventricular fibrillation.

The MultiFib project aims to remedy this deficit by developing a multimodal imaging fibre optic probe, capable of combining the morphological and biochemical characterisation of arrhythmogenic substrates at high optical resolution as a guidance tool for cardiac ablation. MultiFib will integrate optical coherence tomography, second harmonic generation and Raman spectroscopy for the first time in a single fibre optic probe, so enabling structural and biochemical mapping combined with conventional electrical measurements for an unprecedented assessment of the myocardial properties and an identification of the pathological properties. This will also provide a way of assessing the effectiveness of ablation in real time. Consequently, the availability of such a probe will significantly increase the eligibility of patients of all genders requiring treatment for cardiac electrical disorders with catheter ablation therapy. 

RHYTHM

 

 

Repolarization HeterogeneitY imaging for personalised Therapy of Heart ArrhythMia

Despite all the information provided by electrocardiograms and genetic profiling, doctors do not currently have the means to identify in advance patients who will die from sudden cardiac death. The main objectives of this network are to use a detailed understanding of the mechanism of sudden cardiac death to identify patients at risk of sudden death and to develop new tailored therapies to prevent it.

This project received funding from the “Leducq Foundation” as part of the "Transatlantic Networks of Excellence Program" (Research Agreement No. 16 CVD 02).

More information on the website : https://rhythm-network.ihu-liryc.fr/

PersonalizedAF

  

PersonalizedAF - Personalized Therapies for Atrial Fibrillation. A translational approach

New treatment strategies and the progress achieved in research on AF mechanisms and substrate evaluation methods to date have not been commensurate with an equivalent development of the knowledge and technologies required to individually characterize each patient in search of the most efficient therapy.

PersonalizeAF addresses this challenge by delivering an innovative multinational, multi-sectorial, and multidisciplinary research and training programme in new technologies and novel strategies for individualized characterization of AF substrate to and increase treatments' efficiency.

With this purpose, PerlonalizeAF partnership aggregates relevant scientific staff from the academic and clinical world with highly specialised biomedical companies wich will be involved in a high-level personalised training programme that will train a new generation of highly skilled professionals and guarantee ESRs and future PhD students outstanding Career Opportunities in the biomedical engineering, cardiology services and medical devices sectors.

SICVALVES

   SICVALVES : Multiscale modeling of valvular heart diseases - Understanding the mechanisms of adverse remodeling to improve precision medicine

 

The incidence of valvular heart diseases (VHD) in aging populations is increasing dramatically and is becoming a serious health burden. Although the majority of patients are treated effectively by various surgical or interventional methods, there is a large need for improving our understanding of disease mechanisms (knowledge gain) and precision treatment planning (clinical benefit), also with regard to significant gender differences prevalent in VHD.

Our main goal is to develop and validate computational models to investigate the mechanisms responsible for the transition from adaptive to maladaptive hypertrophy (including gender differences) and to aide clinicians in better planning of therapies.

Existing hemodynamic and electromechanical models will be optimized for individual cases using a pool of data from our own previous trials.