European projects

ECSTATIC

Electrostructural Tomography – Towards Multiparametric Imaging of Cardiac Electrical Disorders

 

The aim in this ERC project is to achieve a major advance in the way cardiac electrical diseases are characterised and thus diagnosed and treated, through the development of a novel non-invasive modality (Electrostructural tomography), combining magnetic resonance and non-invasive cardiac mapping technologies. This initiative will open a new field of research at the interface between imaging and electrophysiology, generating novel semiology with the potential to modify the current classification of cardiac electrical diseases. The results of this project can be expected to dramatically impact the tailored management of cardiac electrical disorders, with potential applications for diagnosis, risk stratification/patient selection, and guidance of pacing and catheter ablation therapies.

 

This study received financial support from the "European Research Council" in the framework of ‘Horizon 2020’, the EU Research and Innovation programme from 2014 to 2020: ERC-2016-STG, (Grant Agreement n° 715093).

 

Project file

PUSHCART

Personalized MultiSystems simulations for Honing Cardiac Resynchronization Therapy

 

This project will bring together electrical, mechanical and hemodynamic function in the most detailed multiphysics, multiscale representation of the heart to date. Tightly coupled electromechanical behavior will interface to a circulatory model providing the appropriate boundary conditions to the mechanical model and form a closed circuit. Personalized models will be constructed based on imaging, non-invasive electrical measurements and hemodynamic performance. A complete multi-system model is needed to understand lead placement in Cardiac Resynchronization therapy due to non-electrical factors which have too long been ignored. Validating on detailed experimental studies, retrospective and prospective studies will help us develop a predictive tool to determine optimal CRT lead placement.

 

This study received funding from the ERA-Net ERACoSysMed, “collaboration on systems medicine funding to promote the implementation of systems biology approaches in clinical research and medical practice" (Agreement n°ANR-15-CMED-0003-01)

 
CORDIS3D

CORDIS 3D Marie Curie International Research Staff Exchange Scheme

 

CORDIS3D is an exchange partnership bringing together four leading centres with unique and complementary expertise in order to systematically study the structural substrate of propagation and arrhythmia in the normal and failing heart and in heart failure. Arrhythmias studied will be the role of Purkinje Fibres in ventricular fibrillation, pulmonary venous cuff re-entry in atrial fibrillation, the role of structural changes in myocardial infarction in ventricular fibrillation and right ventricular outflow tract ventricular tachycardia. Tissue studied will include hearts from relevant animal disease models, post-mortem/operative human tissues. Disease models studied will include experimental models of infarction and right heart failure. Structural imaging will be accompanied by 3D-electrophysiological recording and computational modelling to enable investigation of the structure function relationship.

 

"The research leading to these results received funding from the European Union - Marie Curie International Research Staff Exchange Scheme."

SYMPHONY

Sudden Cardiac Death and Electrical Dyssynchrony Mediated by Purkinje-His Dysfunctional Activity

 

The main objectives of SYMPHONY are (i) to advance our fundamental understanding in the mechanisms underlying sudden cardiac deaths and electrical dyssynchrony in heart failure, with a strong focus on the specialized ventricular conduction network and (ii) to improve current preventive, diagnostic and treatment methods for these life-threatening cardiac electrical disorders.

 

SYMPHONY is an inherently multi-disciplinary project that will benefit from a wide array of state-of-the-art methodologies and expertise available in our institute, both in fundamental and clinical sciences.

 

Les recherches menant aux présents résultats ont bénéficié du financement de "European Research Council" dans le cadre de  "European Union's Seventh Framework Programme" (FP / 2007-2013) / ERC Grant Accord n. ERC-2012-ADG 20120314 '.

Research projects

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