Repolarization HeterogeneitY imaging for personalised Therapy of Heart ArrhythMia
Even with all of the information provided by electrocardiograms and genetic profiling, todays’ physicians are unable to identify in advance those patients who will die from sudden cardiac death (SCD). The main objectives of this network are to use a detailed understanding of the mechanism of SCD to identify patients who are at risk for sudden death, and to develop novel patient-specific therapies to prevent it. Members of this network will focus on abnormal ventricular repolarization heterogeneity, measurable electrical events in the heart that are associated with a lethal disturbance of the normal heart rhythm called ventricular fibrillation, believed to be the cause of sudden cardiac death in most patients. The network, composed of world-leading experts with highly complementary knowledge in cardiac repolarization and SCD, will see for the first comprehensive study of human repolarization abnormalities as a mechanism of SCD.
This study received financial support from the ‘Fondation Leducq"d in the framework of the Transatlantic Networks of Excellence Program grant (Research Agreement n°16 CVD 02).