National projects

SIMRIC

Mechanically realistic pedagogical simulator for cardiac interventions

 

Over the last few years, procedures consisting of introducing catheters into the heart, improve the prognosis of patients in arrhythmia applying therapy on focused pathogenic areas. For patients suffering from heart failure, a possible therapy consists of introducing stimulation leads to resynchronize the ventricles.

Despite the ability to simulate all aspects of this type of intervention (introduction of the catheter, electrical signals, imaging, ...), there is not yet a simulator integrating all these characteristics.

The objective of this project was to develop a simulator for manipulating electrophysiological catheters on a mechanically realistic model and to propose to the operator different realistic scenarios of arrhythmias with electrical signals.

 

The SIMRIC project received funding from the Bordeaux IDEX as part of the Future Investment Program.
 

PURKINJE CRA

Characterization of the Purkinje Network from cell to organ, based on cell tissue imaging and clinical data

 

This project aims to characterize the behavior and structure of the Purkinje Network (RP) in order to better understand its role in the genesis of arrhythmias and to develop new interventional therapies. This involves developing new imaging techniques, performing experiments at cellular and tissue levels, acquiring clinical records of the electrical activity of the RP, and integrating all of these data into a computer model. This model will help to better understand how the observed dysfunctions at cellular or tissue level degenerate into organ-level arrhythmias allowing a better stratification of patients at risk.
 

This project received financial support from "Région Aquitaine Limousin Poitou-Charentes" in the framework of call for projects Research 2016 (Agreement  n°2016-1R30113)

Equipex MUSIC

Multi-modality platform for specific imaging in cardiology

 

The MUSIC project will create a multi-modal exploration platform, combining different existing technologies so as to enable multi-parametric assessment of cardiac electrical diseases and guide therapy. The equipment will include MRI, Fluoroscopy, 3D localization and invasive / non-invasive electrophysiological mapping systems - each of which are currently being used separately due to the unavailability / non-existence of the platform that we are proposing propose through this project/this project proposes. With such a platform, developed by academics, different sets of data from multiple vendors and technologies will be interconnected and registered under the same spatio-temporal coordinates. MUSIC will allow a unique piece of equipment to be installed in the hospital to treat patients.

 

This work received support from the French Government managed by the National Research Agency (ANR) under the program "Investissements d'avenir" with the reference  "ANR-11-EQPX-0030."

FFC ROTOR

Mechanisms of sudden cardiac death

 

The main goal of this project is to assess fibrosis and electrophysiological remodeling of the atria, to characterize the re-entrant "drivers" ("rotors") or focal "drivers", perpetuating atrial fibrillation and to analyze their relationship with the atrial structure changes. Specifically, we aim to establish a relationship between reentry and structural remodeling. This project will help to clarify how the structural remodeling has a role in the perpetuation of AF and rotors which would pave the way for new diagnostic (signal processing) and therapeutic (optimal site for thermoablation procedure) algorithm prospects.

 
HR-CEM

High resolution numerical models for cardiac electrophysiology

 

The objectives of the HR-CEM project are:

  • to build high-resolution models of the whole heart and torso including the 4 chambers and the specialized conduction network.
  • to propose high-order and verified numerical techniques, load-balancing strategies and high-performance numerical software in order to implement the models defined above numerically.
  • to construct numerical heart models and assess their performance validation against experimental data provided by LIRYC. Both animal and human data will be considered. The interaction with experimental data will be twofold: First, the data will directly contribute to objective 1 on modelling. Second, the numerical implementation of these models will be compared to in-vivo and ex-vivo electrical recordings for validation. Ultimately, the numerical models will become predictive.

 

This study received financial support from the ‘Agence Nationale de la Recherche (ANR)’ in the framework of the MONU Programme 2013 (Agreement n°ANR-13-MONU-0004-04)

MIGAT

Multimodal Image processing software to Guide Cardiac Ablation Therapy

 

Cardiac electrical disorders are a major cause of human mortality and morbidity worldwide. Catheter ablation therapy has become part of international recommendations for the management of both atrial and ventricular arrhythmia. Advanced catheter localization systems now enable 3-dimensional mapping of cardiac electrical activity. The integration of 3-dimensional imaging data acquired prior to the procedure and its merging with the mapping geometry has been shown as feasible.

 

MIGAT objectives are to develop within 3 years software with subsequent CE/FDA marking able to process and fuse multi-modal non-invasive 3-dimensional data and to clinically validate multi- modal data integration for the guidance of cardiac ablation.

 

This work received funding from the ANR (ANR-13-PRTS-0014-01).

NOVELECGi

NOn-invasiVE three-dimensionaL ElectroCardioGraphic imaging of trigger and substrate

 

Non-invasive electrocardiographic imaging is a promising new tool to provide high resolution panoramic imaging of cardiac electricity from chest electrodes. We have recently successfully applied this tool to the study and treatment of atrial fibrillation and the current project will extend our previous work to the study of ventricular fibrillation. However, this will require validation of novel signal analysis tools and improvements to the solution of the inverse problem. The main objectives of NOVELECGi are therefore (i) to apply and further develop non-invasive threedimensional electrocardiographic imaging of ventricular fibrillation, (ii) to advance our fundamental understanding in the trigger and substrate mechanisms underlying sudden cardiac death, and (iii) to improve current preventive, diagnostic and treatment methods for these life-threatening cardiac electrical disorders.


NOVELECGi is a fundamental and clinical research project that will lead to significant progress in the understanding, prevention and treatment of sudden cardiac death.

TACIT

MR guided cardiac RF ablation

 

The objectives of this research project are to develop fast and reliable cardiac MR thermometry in order to improve the efficiency and safety of Radio-frequency ablation (RFA) for patients. RFA using a dedicated catheter has proved effective in treating cardiac arrhythmia. However, the lack of real time visualization of thermal lesion formation in current clinical practice prevents the physician from evaluating the size of the lesion during the procedure.

 

In this “TACIT” project, MR acquisition methods, real-time image processing and dedicated MR compatible instrumentation will be developed to allow online visualization of thermal lesion formation during the RF ablation procedure.

 

This work received funding from the 'ANR (ANR-11-TecSan-003-01).

TEMPO

Trigger and substratE Mechanisms of Pulmonary vein ectOpy

 

The main objective of the TEMPO research project is to gain a better understanding of the trigger and substrate mechanisms underlying PV ectopy and the onset of paroxysmal AF. Specifically, this project will consist of 4 workpackages that will aim at: (i) a comprehensive molecular, cellular and clinical characterization of PV electrophysiology, with a special emphasis on afterdepolarizations as a mechanism of ectopy; (ii) determining the effects of stretch on PV ectopy from the molecular level to the clinical situation; (iii) investigating the effects of increased adrenergic and vagal stimulation upon PVs from the single cell to the patient; and (iv) reconstructing the complex myofiber architecture of the PVs, before and after ablation, and investigating its role on AF initiation.

 

This work received funding from the ANR (ANR-12-BSV1-0029-02).

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