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Cellular electrophysiology & molecular biology

From the electrocardiogram to the cell

An electrocardiogram (ECG) records the electrical activity of the heart (required to trigger cardiac contractions).

 

This electrical activity involves a myriad of sequentially excited cells in a complex process: several types of ion channels, pumps and exchangers at the cell membrane level are activated to enable electrical signal generation and conduction (the action potential) which triggers contractions.

 

The molecular and cellular electrophysiology team explore the mechanisms of cardiac rhythm and conduction disorders on the cell and molecular level. Several advanced techniques are used such as the double patch clamp that measures electrical currents between two cells, microspectrofluorometry and confocal microscopy for high resolution imaging of subcellular processes and several molecular biology techniques, allowing us to investigate genetic and protein changes in cardiovascular pathologies.

TEAM
Fabien Brette
Researcher - Team Leader
Edward White
Visiting Professor
Sébastien Chaigne
Engineer
Gilles Bru-Mercier
Post-doctoral Researcher
Sabine Charron
Engineer
Marion Constantin
Engineer Assistant
Alice Recalde
Post-Doctoral Researcher
Matthieu Douard
PhD Student
Thomas Hof
Postdoctoral Researcher