Tissue electrophysiology

Electrical tornadoes in the human heart

The atrial and ventricular fibrillation team has made major advances in the understanding of the different types of cardiac fibrillation, particularly with the application of non-invasive mapping enabling the study of cardiac tissues with 2000 images per second. This approach allowed us to demonstrate the ‘electrical tornadoes’ that cause these arrhythmia and to study their mechanisms.

 

The electrophysiological properties of pulmonary veins and the dynamics of atrial fibrillation were thus characterized. Researchers from the Institute have identified the source of these rhythmic tornadoes triggering sudden cardiac death in the Purkinje fibers. Liryc characterizes the role of the Purkinje fibers in the heterogeneity of ventricular repolarization and in the maintenance of ventricular arrhythmia. Liryc researchers have also identified the electrophysiological and structural arrhythmogenic properties in ventricular fibrillation in asymptomatic patients.

 

Liryc is currently working on a new research program on human donor hearts. For the first time, the specific properties of the pulmonary veins and the Purkinje network that are associated with cardiac fibrillation have been studied. These preliminary observations offer new perspective for the development of targeted therapeutic approaches. 


 

TEAM
Olivier BernusScientific Director - Professor - Team Leader
Igor EfimovVisiting Professor
Ruben CoronelVisiting Professor
Charly BeltermanLaboratory Technician
Richard WaltonPost-Doctoral Researcher
Line PourtauPost-Doctoral Researcher
Caroline CrosPost-Doctoral Researcher
Caroline Pascal-AuclercPost-Doctoral Researcher
David BenoistPost-doctoral Researcher
Carolina Carlos-SampedranoPost-doctoral Researcher
Marion ConstantinEngineer Assistant
Lisa Amalie GottliebPhD Student
Marine MartinezPhD Student
Virginie DubesPhD Student
Wesam MullaPhD Student

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