ECSTATIC

ECSTATIC

Project ID : 715093

Funded under: H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)

 

Electrostructural Tomography - Towards Multiparametric Imaging of Cardiac Electrical Disorders

From 2017-02-01 to 2022-01-31, ongoing project

 

Project details

Total cost:
EUR 1 475 000

Topic(s):
ERC-2016-STG - ERC Starting Grant

EU contribution:
EUR 1 475 000

Call for proposal:
ERC-2016-STG

Coordinated in:
France

Funding scheme:
ERC-STG – Starting Grant

 

 

 

 

 

 

 

 


Objectives

Cardiac electrical diseases are directly responsible for sudden cardiac death, heart failure and stroke. They result from a complex interplay between myocardial electrical activation and structural heterogeneity. Current diagnostic strategy based on separate electrocardiographic and imaging assessment is unable to grasp both these aspects. Improvements in personalised diagnostics are urgently needed as existing curative or preventive therapies (catheter ablation, multisite pacing, and implantable defibrillators) cannot be offered until patients are correctly recognised.

Our aim is to achieve a major advance in the way cardiac electrical diseases are characterised and thus diagnosed and treated, through the development of a novel non-invasive modality (Electrostructural Tomography), combining magnetic resonance imaging (MRI) and non-invasive cardiac mapping (NIM) technologies.

The approach will consist of: (1) hybridising NIM and MRI technologies to enable the joint acquisition of magnetic resonance images of the heart and torso and of a large array of body surface potentials within a single environment; (2) personalising the inverse problem of electrocardiography based on MRI characteristics within the heart and torso, to enable accurate reconstruction of cardiac electrophysiological maps from body surface potentials within the 3D cardiac tissue; and (3) developing a novel disease characterisation framework based on registered non-invasive imaging and electrophysiological data, and propose novel diagnostic and prognostic markers.

This project will dramatically impact the tailored management of cardiac electrical disorders, with applications for diagnosis, risk stratification/patient selection and guidance of pacing and catheter ablation therapies. It will bridge two medical fields (cardiac electrophysiology and imaging), thereby creating a new research area and a novel semiology with the potential to modify the existing classification of cardiac electrical diseases.

Host Institution

UNIVERSITE DE BORDEAUX

Place Pey Berland 35
33000 Bordeaux
France
Activity type: Higher or Secondary Education Establishments

EU contribution: EUR 1 475 000

 

 

 

 

 

 

Beneficiaries

Global EU contribution: EUR 1 475 000

Université de Bordeaux

Place Pey Berland 35
33000 Bordeaux
France
Activity type: Higher or Secondary Education Establishments

 

Inria

Domaine de Voluceau Rocquencourt
78153 Le Chesnay Cedex
France
Activity type: Research Organization

 

 

 

 

 

 

 

 

 

 

 

 

Principal Investigator

Prof. Hubert Cochet, MD, PhD

Cardiology, Radiology
Head of Cardiac Imaging in Bordeaux University Hospital
Head of cardiac imaging and software applications within LIRYC Electrophysiology and Heart Modeling Institute
Hubert.cochet@chu-bordeaux.fr

Maxime Sermesant, PhD

Research Scientist
Cardiac modelling, machine learning, medical imaging
maxime.sermesant@inria.fr

 

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